文章基本信息

标题：Rosmarinus officinalis L. leaf extract improves Anxity impairment induced by tropane alkaloids extracted from Datura stramonium
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作者：Latifa Didou ; Fatima-Zahra Azzaoui ; Ahmed omar touhami Ahami 等
期刊名称：E3S Web of Conferences
印刷版ISSN：2267-1242
电子版ISSN：2267-1242
出版年度：2021
卷号：319
页码：1-5
DOI：10.1051/e3sconf/202131901059
语种：English
出版社：EDP Sciences
摘要：The alkaloid extract of datura stramonium (rich of atropine, hyoscyamine, scopolamine) is used to evaluate its effect on the central nervous system in rats (locomotion, anxiety). The animals received the alkaloid extract of datura by intraperitoneal injection. However, after the injection a group of rats got an inhibitory treatment contain flavonoids extracted from Rosmarinus officinalis. At the dose of 50 mg/kg/body weight of the alkaloid extract, the female rats have shown a reduction of locomotor activity and an induction of an anxiogenic effect. In the other hand, the mixture of Datura stramonium and Rosmarinus officinalis showed a neuroprotective action with regard to the disorders induced by extracts of Datura stramonium.