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标题：A ingesto de cafeína como fator protetor no desenvolvimento e na progresso da Doena de Parkinson e na Doena de Alzheimer: uma reviso integrativa
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作者：Tatiana Lima Paiva ; Giovanni Ferreira Santos ; Joo Otávio Bayo Coutinho 等
期刊名称：Research, Society and Development
电子版ISSN：2525-3409
出版年度：2022
卷号：11
期号：8
页码：1-12
DOI：10.33448/rsd-v11i8.31424
语种：English
出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：Introduction: The prevalence of Alzheimer's disease (AD) and Parkinson's disease (PD) tends to increase with the aging population. Currently, the therapeutic schemes for these diseases cannot achieve a cure and are also not frequently updated, which highlights the need for other options to improve the quality of life of these patients. Given that these dementia syndromes have a multifactorial etiology, diet, through coffee, has shown significant evidence in neuronal degeneration, which is one of the main aspects altered in the development of these pathologies. Methodology: This is an integrative review, which sought to answer what the possible effects of caffeine as a protective factor in the development and progression of AD and PD, in the databases: Virtual Health Library (VHL) National Library of Medicine (PubMed MEDLINE) and Scientific Electronic Library Online (Scielo). Results and Discussion: Caffeine acts in the central nervous system (CNS) by mimicking the adenosine receptors, more concentrated in the A1R and A2aR receptors. As a competitive antagonist, caffeine could possibly reduce the processes of b-amyloid plaque formation in AD and reduce neuroinflammation and neurodegeneration in PD, besides other possible mechanisms. Conclusion: The delimitation of a consensus on the dose/effect relation resulting from the use of caffeine is difficult to establish and a consensus is not yet observed; however, it is possible to observe that an intake between 200mg to 511mg per day could bring beneficial effects both in PD and in AD, overcoming the possible side effects.
关键词：Caffeine;Alzheimer's Disease;Parkinson's Disease;Neuroprotection;Neurodegeneration.