文章基本信息

标题：Análise imunoistoquímica e histomorfométrica do endométrio de ratas em estro permanente tratadas com melatonina, metformina e citrato de clomifeno
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作者：Leandro Sabará de Mattos ; Leonardo Augusto Lombardi ; Marcio Luis Alves Moura 等
期刊名称：Research, Society and Development
电子版ISSN：2525-3409
出版年度：2022
卷号：11
期号：7
页码：1-16
DOI：10.33448/rsd-v11i7.29995
语种：English
出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：Objective: To evaluate the effects of melatonin, metformin and clomiphene citrate on the endometrium of polycystic ovary syndrome model rats. Methods: Seventy-eight rats were divided into 13 groups and two experiments (prevention and treatment). After exposure, all animals were anesthetized and the uterine horns were removed and submitted to hematoxylin and eosin staining and immunohistochemistry (Ki-67 and Vegf). The data obtained were submitted to Student's t test (p<0.05). Results/Conclusion: Melatonin, metformin and clomiphene citrate do not promote proliferative and angiogenic effects on the endometrium of rats in permanent estrus, however, melatonin has a more significant trophic effect on the endometrial stroma, which did not interfere with its thickness, while that metformin had a more significant trophic effect on endometrial glandular epithelium, therefore, these effects are similar both before and after PCOS induction by continuous light exposure.
关键词：Endometrium;Permanent estrus;Health teaching;Melatonin;Metformin;Clomiphene citrate;Rats.