文章基本信息

标题：A efetividade do plasma convalescente no tratamento da COVID-19: reviso sistemática
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作者：Marcia Rodrigues dos Santos ; Adriana Carla Bridi ; Thiago Quinellato Louro 等
期刊名称：Research, Society and Development
电子版ISSN：2525-3409
出版年度：2022
卷号：11
期号：4
页码：1-12
DOI：10.33448/rsd-v11i4.26877
语种：English
出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：The aim of this review was to analyze the therapeutic effectiveness of convalescent plasma used in patients with diagnosis confirmed of COVID-19. Methods: This is a systematic literature review propose in the Cochrane Collaboration Manual, with the elaboration of the PICO strategy, in which the Pubmed/Medline, BVS, Embase, CINAHL, LILACS, Cochrane and Google Scholar databases were used. Randomized clinical trials and systematic reviews were selected. We found 1249 articles, applying the inclusion and exclusion criteria, 8 articles were selected. AMSTAR-2 was used to assess the risk of bias and the quality of the evidence from the studies included in the systematic review was evaluated by the Grading of Recommendations Assessment Development and Evaluation (GRADE). Results: Regarding the results, studies with a low level of Oxford evidence predominated (75%). Four studies (50%) showed evidence level 2B. However, one response to this analysis was the low quality of the evidence and little confidence in the results of the studies. The qualitative synthesis revealed that although it was able to reduce the viral load, the use of convalescent plasma does not contribute in isolation to the reduction of the load. Conclusion: It is concluded that convalescent plasma is effective for reducing viral load and that many studies are still lacking, particularly economic analysis of effectiveness, as it is a cheap technology with potential for incorporation into the SUS.
关键词：COVID-19;Convalescent plasma;SARS-CoV-2.