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标题：Perfil químico e atividade antimicrobiana de abarema cochliacarpos
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作者：Pietra Alexia Lima dos Santos ; Ludmila Cruz dos Santos ; Ras de Araujo Costa 等
期刊名称：Research, Society and Development
电子版ISSN：2525-3409
出版年度：2022
卷号：11
期号：4
页码：1-14
DOI：10.33448/rsd-v11i4.27226
语种：English
出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：Abarema cochliacarpos is an endemic species from Brazil, it belongs to the Fabaceae family and is popularly known as barbatimo, being present in the Brazilian caatinga and cerrado. In Sergipe, its use is in the form of teas for anti-inflammatory and healing activities. As objects of this study, the leaves of the plant were used in order to qualitatively know the chemical constituents of the fractions obtained from the crude extract: chloroform fraction (FCL), hexane fraction (FHX), ethyl acetate fraction (FAE) and hydromethanolic fraction ( FHM) through phytochemical prospection by colorimetric assays, being detected the presence of secondary metabolites such as phenols, tannins, flavonols, catechins, steroids, triterpenoids and saponins. In the antimicrobial analysis, only two fractions showed inhibition halos. The FAE for Staphylococcus aureus (19.3 mm), Enterococcus durans hirae (10 mm), derived Escherichia coli (9.6 mm) and derived Pseudomonas aeruginosa (15 mm) strains, and the FCL for the E. durans strain hirae (9 mm). In the minimal inhibitory concentration (MIC) the FAE excelled with 12.5 μg.mL-1 for S. aureus and E. durans, while the FCL obtained 25 μg.mL-1 for E. durans. As for the cytotoxic analysis, FAE at the concentrations tested did not favor cell viability in 75%, showing antiproliferative capacity, except for FLC at 20 μg.mL-1. FAE and FCL showed antioxidant properties and obtained an antimicrobial effect, in addition to having metabolites that corroborate these functions.
关键词：Abarema cochliacarpos;Leaves; biological activity;Cytotoxic analysis;Phenolic compounds.