文章基本信息

标题：Síndrome de Apert: desafios do diagnóstico pré-natal ao tratamento com ênfase na base genética
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作者：Joo Victor Carvalho da Paz ; Luanna Oliveira Alves ; Francisco Airton Veras de Araújo Júnior 等
期刊名称：Research, Society and Development
电子版ISSN：2525-3409
出版年度：2022
卷号：11
期号：4
页码：1-9
DOI：10.33448/rsd-v11i4.27933
语种：English
出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：Introduction: The perfect definition is a definition of rare feet. Its management should be early and multidisciplinary. Almost all bones are stoid and have sagitted skulls and also coronal sagitoids. Methodology: The search platform on the following sites: SciELO, Brazilian Journal of Neurosurgery, Arquivos Ciência Saúde, American Journal of Neurosurgery, PUBLAB and PUBMED. The descriptors were: “Apert syndrome”; “Craniosynostosis”; “Fronto-orbital advancement” e and “Hydrocephalus”. Outcome and Discussion: The middle third of the face in Apert syndrome is underdeveloped and retruded; evaluation subset has a palatal. The hand in Apert syndrome always includes fusion of the three middle fingers; contact and the fifth finger are also sometimes involved. Its severity lies in the coexistence of several malformations with risk of chronic intracranial hypertension responsible for blindness and mental weakness. Multiple airway obstruction may be present and may be due to narrowing of the nasal passages, tongue-based airway obstruction, and/or tracheal abnormalities. Nonprogressive ventriculomegaly is present in most true sets, with a small subset having hydrocephalus. A genetic alteration genitourinary tract alterations, true gastrointestinal malformations and genitourinary tract anomalies. Conclusion: Apert syndrome is one of the most serious craniofacial disorders. Most need a cranial vault surgery intervention, and many more need surgery. The need for average facial advancement is also very prevalent.
关键词：Apert syndrome;Craniosynostosis;Fronto-orbital advancement;Hydrocephalus.