文章基本信息

标题：Pneumonia Associada à Ventilao Mecanica (PAVM) assistida pela quitosana
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作者：Luiza Arago Paiva Pires Ferreira Mendes ; Amália Ramos de Sousa ; Isabelle Vasconcelos Rodrigues 等
期刊名称：Research, Society and Development
电子版ISSN：2525-3409
出版年度：2022
卷号：11
期号：3
页码：1-12
DOI：10.33448/rsd-v11i3.26581
语种：English
出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：Introduction: Ventilator-associated pneumonia (VAP) is one of the main causes of nosocomial infections in ICUs, which leads to an increase in length of stay, medical expenses, increases in morbidity and mortality rates, with an increase in antibiotic-resistant bacteria, corroborates in the application of new biomaterials, therefore, chitosan is studied because it has several functional properties, such as antimicrobial. Methodology: The research carried out is a systematic review by consulting online databases to collect information. The main journal databases used for active article searches were: ANVISA, WHO, PUBMED, Science Direct, SCIELO. Results and discussions: The microbial interaction within the biofilm contributes to the PAVM, in this sense there is an implication in antimicrobial therapy, however the resistance to the drugs used validates the need to find new antimicrobial agents, chitosan and its derivatives have versatility, low cost and broad spectrum of antimicrobial activity against gram-positive and gram-negative bacteria, filamentous fungi and yeasts. Conclusion: it appears that a probable way to combat bacterial infections related to mechanical ventilation is chitosan and its derivatives, they have relevant antimicrobial activities and great potential for their use in combating the tenacity of microorganisms.
关键词：Mechanical ventilation;Pneumonia;Anti-bacterial;Chitosan;Biofilm.