文章基本信息

标题：Efeitos colaterais associados ao tratamento da Leucemia Promielocítica Aguda: reviso sistemática
本地全文：下载
作者：Anderson Silva Salles Filho ; Helton Oliveira Campos
期刊名称：Research, Society and Development
电子版ISSN：2525-3409
出版年度：2022
卷号：11
期号：3
页码：1-13
DOI：10.33448/rsd-v11i3.26914
语种：English
出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：Acute Promyelocytic Leukemia (APL) is a type of cancer that mainly attacks blood cells and requires intensive treatments that damage and directly affect health. The treatments used to control APL associated with drugs affect the individual, manifesting side effects. This systematic review aimed to analyze the side effects associated with the treatments used for APL. For this, a systematic review was conducted according to the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analysis). The literature search was carried out in the following databases: PubMed and Web of Science using combinations of the following keywords in English and Portuguese: acute myeloid leukemia, promyelocytic leukemia, M3, treatment, side effects and drugs. Studies that met the following criteria were included in the systematic review: (I) the participants were diagnosed with APL, (II) the patients underwent a treatment protocol for the pathology, (III) the side effects associated with the treatment were described. A total of 31 articles were selected for inclusion in the systematic review. The most frequent side effects associated with the treatment of APL found were: skin reactions, gastrointestinal discomfort, nausea, vomiting and migraine. Based on the results found in this systematic review, it was observed that some side effects frequently appear in patients with APL, regardless of the type of treatment used, namely: nausea, vomiting, skin reactions, migraine and gastrointestinal discomfort.
关键词：Therapeutics;Hematologic agents;Acute myeloid leukemia.