文章基本信息

标题：Inhibitory Effect of (-)-myrtenol alone and in combination with antifungal agents on Candida spp.
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作者：Bruno Bezerra Cavalcanti ; Hermes Diniz Neto ; Walicyranison Plinio da Silva-Rocha 等
期刊名称：Research, Society and Development
电子版ISSN：2525-3409
出版年度：2021
卷号：10
期号：15
页码：1-6
DOI：10.33448/rsd-v10i15.22434
语种：English
出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：The aim of this study was to examine the effects of (-)-myrtenol alone and combined with antifungal agents against Candida spp. The Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration of (-)-myrtenol and fluconazole against C. albicans and C. parapsilosis strains was obtained using CLSI guidelines. Combination of (-)-myrtenol with antifungal drugs was determined by checkboard test. The (-) myrtenol showed MIC ranging from 256 to 512 μg/mL against both species assay. And the MFC was 512 μg/mL, demonstrated nature fungicidal (MFC/MIC Candida spp. In addition, Combination of antifungal agents and (-) myrtenol reduces the effective concentrations of both the agents with synergistic to additive effects. Therefore, (-) myrtenol has potential to be developed into an antifungal agent.
关键词：Monoterpenes;Antifungal activity;Natural products;Alternative therapy.