文章基本信息

标题：The Occurrence of Migraine Auras and Possible Triggers
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作者：William Burke 1,2,3* , John Robinson
期刊名称：Health
印刷版ISSN：1949-4998
电子版ISSN：1949-5005
出版年度：2014
卷号：06
期号：19
页码：2688-2696
DOI：10.4236/health.2014.619307
语种：English
出版社：Scientific Research Publishing
摘要：Our aim is to determine the cause(s) of migraine auras. Our understanding of how migraines and migraine auras originate is very imperfect. An important observation is that migraines occur more frequently in women at reproductive age than in men at a similar age. This suggests that gonadal hormones may be relevant triggers. The occurrence of classical (typical auras without headache) auras in one author (WB) has been recorded. Every aura in six years (85) has been noted, studied and analysed statistically. The auras occur predominantly in Spring and Autumn, especially in the longer reproductive season of Spring. This association is supported statistically. The results support the idea of gonadal hormones as relevant triggers, the strongest candidate being estrogen. Basic mechanisms underlying the auras are discussed, especially the phenomenon of cortical spreading depression. We also propose that both auras and migraines depend upon previous injury to the head or to the brain, giving rise to a condition of “deafferentation hypersensitivity”.
关键词：Migraine Aura; Equinox; Estrogen; Spring; Autumn; Deafferentation Hypersensitivity