文章基本信息

标题：Effects of Ashwagandha (Roots of Withania somnifera) on Neurodegenerative Diseases
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作者：Tomoharu Kuboyama ; Chihiro Tohda ; Katsuko Komatsu 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2014
卷号：37
期号：6
出版社：The Pharmaceutical Society of Japan
摘要：Neurodegenerative diseases commonly induce irreversible destruction of central nervous system (CNS) neuronal networks, resulting in permanent functional impairments. Effective medications against neurodegenerative diseases are currently lacking. Ashwagandha (roots of Withania somnifera Dunal) is used in traditional Indian medicine (Ayurveda) for general debility, consumption, nervous exhaustion, insomnia, and loss of memory. In this review, we summarize various effects and mechanisms of Ashwagandha extracts and related compounds on in vitro and in vivo models of neurodegenerative diseases such as Alzheimer’s disease and spinal cord injury.