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标题：Vitamin D in the prevention and treatment of periodontal diseases: an integrative review
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作者：Marlon Mezadri Layber ; Alyne Barreto Mesquita de Goés ; Camila Vilar de Oliveira Villarim 等
期刊名称：Research, Society and Development
电子版ISSN：2525-3409
出版年度：2021
卷号：10
期号：13
页码：1-9
DOI：10.33448/rsd-v10i13.20738
语种：English
出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：Introduction: Vitamin D is synthesized from 7-dehydrocholesterol during a photochemical reaction, under the effect of ultraviolet radiation on the skin, obtained from food. It is hydroxylated in the liver to 25-hydroxyvitamin D3 (25(OH)D3). It is an active metabolite, which maintains the balance of calcium and phosphorus concentration in the blood, in addition to helping bone remodeling. Vitamin D deficiency promotes rickets in children and osteoporosis in adults, with a risk of bone fracture. Vitamin D acts in the pathogenesis of periodontal diseases via immunomodulation, increases mineral density and reduces bone resorption, which is important in combating agents that cause periodontal diseases. Objectives: Evaluate the importance of vitamin D in the prevention and treatment of periodontal diseases. Methods: A search was carried out in the PubMed/Medline, Scopus, Scielo, Embase, Web of Science and Google Scholar databases on scientifically proven evidence on the subject. Results: The present review demonstrated the importance of vitamin D in the prevention and treatment of periodontitis and the consequences of its deficiency on the oral health of patients. Conclusion: Vitamin D plays an important role in oral homeostasis and vitamin deficiency results in periodontal disease.
关键词：Calcitriol receptors;Oral pathology;Pathologic bone demineralization;Periodontal diseases;Vitamin D.