文章基本信息

标题：Vitamina D em pacientes com COVID-19: atuais perspectivas
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作者：Ana Beatriz Bessa de Albuquerque ; Alan Lins Fernandes ; Bruna Zavarize Reis 等
期刊名称：Research, Society and Development
电子版ISSN：2525-3409
出版年度：2021
卷号：10
期号：13
页码：1-11
DOI：10.33448/rsd-v10i13.21167
语种：English
出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：The search for therapeutic resources that add to the vaccine and are able to prevent and/or treat COVID-19 suggests vitamin D. Vitamin D is known to play several extra-skeletal roles in the body, particularly in the immune system. This review aims to address the current attributions and perspectives for the use of vitamin D in patients with COVID-19. The search was performed using the Medline (PubMed) database, between May and July 2021, regarding the physiological and immunological roles of vitamin D in respiratory infections, as well as its mechanisms of action, concerning COVID- 19. The results suggest a possible association between serum 25(OH)D concentrations and the clinical setting of COVID-19 (mortality, systemic inflammation, illness severity, mechanical ventilation requirement or admission to the ICU), although the studies found differ in the design, sample size and outcomes, mitigating an accurate between-trial comparison. Therefore, further studies with a well-defined design evaluating the role of vitamin D in the prevention and/or treatment of COVID-19 is still necessary.
关键词：25OHD;Cholecalciferol;Ergocalciferol;SARS-CoV-2;Coronaviruses ;COVID-19.