文章基本信息

标题：Electrophysiological and Pharmacological Properties of the Pulmonary Vein Myocardium
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作者：Iyuki Namekata ; Yayoi Tsuneoka ; Hikaru Tanaka 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2013
卷号：36
期号：1
页码：2-7
DOI：10.1248/bpb.b212020
出版社：The Pharmaceutical Society of Japan
摘要：The pulmonary vein contains a myocardial layer extending from the left atrium, which is receiving attention as the source of ectopic electrical activity underlying atrial fibrillation. Electrophysiological and pharmacological analysis of the pulmonary vein myocardium performed in various experimental animal species have revealed characteristics such as presence of intracellular Ca²⁺ oscillations and low repolarizing potency. The automaticity of the pulmonary vein myocardium is affected by various neurotransmitters, hormones and pharmacological agents. Clarification of the mechanisms and regulation of pulmonary vein automaticity would lead to the development of novel therapeutic strategies and pharmacological agents for atrial fibrillation.
关键词：pulmonary vein myocardium;automaticity;intracellular Ca2+