文章基本信息

标题：Role of 5-Hydroxytryptamine2C Receptors in Marble-Burying Behavior in Mice
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作者：Nobuaki Egashira ; Ryoko Okuno ; Atsunori Shirakawa 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2012
卷号：35
期号：3
页码：376-379
DOI：10.1248/bpb.35.376
出版社：The Pharmaceutical Society of Japan
摘要：We examined the role of 5-hydroxytryptamine_2C (5-HT_2C) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT_2C agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT_2C antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT_2C receptors play a role in marble-burying behavior in mice.
关键词：marble-burying behavior;5-hydroxytryptamine2C receptor;WAY161503;obsessive-compulsive disorder;fluvoxamine;paroxetine