文章基本信息

标题：Recent Advances in the Study on Resveratrol
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作者：Rieko Nakata ; Satoru Takahashi ; Hiroyasu Inoue 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2012
卷号：35
期号：3
页码：273-279
DOI：10.1248/bpb.35.273
出版社：The Pharmaceutical Society of Japan
摘要：Appropriate long-term drinking of red wine is associated with a reduced risk for lifestyle-related diseases such as cardiovascular disease and cancer, making resveratrol, a constituent of grapes and various other plants, an attractive compound to be studied. Historically, resveratrol has been identified as a phytoalexin, antioxidant, cyclooxygenase (COX) inhibitor, peroxisome proliferator-activated receptor (PPAR) activator, endothelial nitric oxide synthase (eNOS) inducer, silent mating type information regulation 2 homolog 1 (SIRT1) activator, and more. Despite scepticism concerning the biological availability of resveratrol, a growing body of in vivo evidence indicates that resveratrol has protective effects in several stress and disease models. Here, we provide a review of the studies on resveratrol, especially with respect to COX, PPAR, and eNOS activities, and discuss its potential for promoting human health.
关键词：resveratrol;cyclooxygenase;peroxisome proliferator-activated receptor;endothelial nitric oxide synthase;silent mating type information regulation 2 homolog 1