文章基本信息

标题：Isolation and Characterization of a Human Intestinal Bacterium Eggerthella sp. CAT-1 Capable of Cleaving the C-Ring of (+)-Catechin and (−)-Epicatechin, Followed by p-Dehydroxylation of the B-Ring
本地全文：下载
作者：Jong-Sik Jin ; Masao Hattori
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2012
卷号：35
期号：12
页码：2252-2256
DOI：10.1248/bpb.b12-00726
出版社：The Pharmaceutical Society of Japan
摘要：We isolated a human intestinal bacterium, capable of cleaving the C-ring and dehydroxylating the B-ring of both (+)-catechin (2 R ,3 S ) and (−)-epicatechin (2 R ,3 R ). Although the strain was classified as Eggerthella ( Eg. ) lenta [named Eg. sp. CAT-1 (JF798636)] by 16S ribosomal RNA (rRNA) gene similarity, it was quite different in substrate specificity from a previously isolated strain, Eg. sp. SDG-2, which takes part in cleavage of the C-ring and dehydroxylation of the 3,4-dihydroxyphenyl moiety (B-ring) of (3 R )-flavan-3-ol derivatives. On the other hand, both Eg. sp. CAT-1 and Eg. sp. SDG-2 showed the same substrate specificity against dehydroxylation of enantiomeric lignans, (+)- and (−)-dihydroxyenterodiol, and (+)- and (−)-dihydroxyenterolactone.
关键词：catechin;human intestinal bacterium;dehydroxylation;Eggerthella lenta