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  • 标题:Reinvestigation of Drugs and Chemicals as Aquaporin-1 Inhibitors Using Pressure-Induced Hemolysis in Human Erythrocytes
  • 本地全文:下载
  • 作者:Takeo Yamaguchi ; Yohei Iwata ; Shingo Miura
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2012
  • 卷号:35
  • 期号:11
  • 页码:2088-2091
  • DOI:10.1248/bpb.b12-00581
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Recently, we have found that pressure-induced hemolysis is enhanced by inhibiting water transport via aquaporin-1 (AQP1), as seen in p -chloromercuribenzoate ( p CMB)-treated erythrocytes. So, using this method we reinvestigated the functions as AQP1 inhibitors of drugs and chemicals such as acetazolamide, sodium nitroprusside, tetraethylammonium ions (TEA+), and dimethylsulfoxide (DMSO). The values of hemolysis at 200 MPa were almost unaffected by acetazolamide or sodium nitroprusside, decreased by TEA+, and increased significantly by DMSO. Furthermore, the erythrocytes were exposed to p CMB in the presence of TEA+ or DMSO. The enhancement effect of p CMB on pressure-induced hemolysis was unaffected by TEA+ but attenuated by DMSO. Taken together, these results suggest that, of drugs and chemicals examined here, DMSO only is an AQP1 inhibitor, but the effect of DMSO is small compared with p CMB.
  • 关键词:aquaporin-1 inhibitor;pressure-induced hemolysis;water transport;human erythrocyte
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