文章基本信息

标题：Enhanced Behavioral Response to Serotonin-Related Agonists in Postweaning Protein Malnourished Mice
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作者：Shoko Sato ; Osamu Nakagawasai ; Takafumi Hayashi 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2012
卷号：35
期号：10
页码：1697-1702
DOI：10.1248/bpb.b12-00194
出版社：The Pharmaceutical Society of Japan
摘要：We investigated whether postweaning protein malnutrition (PM) affects serotonergic systems. Mice were fed a PM diet or normal protein (control) diet from weaning (21 d of age). Twenty days later, we tested for behavioral effects of the selective serotonin (5-HT)_1A receptor agonist 8-hydroxy- N , N -dipropyl-2-aminoteralin (8-OH-DPAT) and the 5-HT releaser d -fenfluramine. The number of head weaving responses induced by 8-OH-DPAT or d -fenfluramine in the PM mice was significantly increased compared with the control diet group. The effects of 8-OH-DPAT and d -fenfluramine were blocked by pretreatment with the selective 5-HT_1A receptor antagonist WAY-100635 (0.01 mg/kg). However, postpubertal (56 d of age) mice fed with the PM diet did not show an enhancement of the 8-OH-DPAT-induced head weaving response. These results indicate the occurence of a supersensitivity of postsynaptic 5-HT_1A receptor in the postweaning PM group. Moreover, they highlight the postweaning stage as a vulnerable period to malnutrition-induced alterations in central serotonergic systems.
关键词：protein malnutrition;serotonin1A;serotonin syndrome;head weaving;post-weaning period;mouse