文章基本信息

标题：Differential Induction of Stearoyl-CoA Desaturase 1 and 2 Genes by Fibrates in the Liver of Rats
本地全文：下载
作者：Tohru Yamazaki ; Hitomi Okada ; Takeshi Sakamoto 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2012
卷号：35
期号：1
页码：116-120
DOI：10.1248/bpb.35.116
出版社：The Pharmaceutical Society of Japan
摘要：The administration of fibrates (fenofibrate, bezafibrate and clofibric acid) to rats induced stearoyl-CoA desaturase (SCD) in the liver, and increased relative expression of mRNAs encoding SCD1 and SCD2 in dose- and time-dependent manners. The magnitudes of the increases in SCD2 mRNA level caused by fenofibrate and clofibric acid were much higher than those of SCD1 at relatively higher doses of the fibrates, and a relatively long time (7 or 14 d) was required for significant induction of SCD2 mRNA expression compared with that of SCD1. Although the absolute number of transcripts for SCD2 was 1,800 times lower than that of SCD1 in the control liver, it was strikingly increased by fibrates. These results suggest that differential regulations operate for the gene expression between SCD1 and SCD2, and that the physiological significance of SCD2 is distinct from that of SCD1 in the liver.
关键词：stearoyl-CoA desaturase;clofibric acid;fenofibrate;rat liver