文章基本信息

标题：Genetic Animal Models of Schizophrenia Related with the Hypothesis of Abnormal Neurodevelopment
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作者：Lingling Lu ; Takayoshi Mamiya ; Takenao Koseki 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2011
卷号：34
期号：9
页码：1358-1363
DOI：10.1248/bpb.34.1358
出版社：The Pharmaceutical Society of Japan
摘要：Accumulating evidence supports the existence of an overlap in genetic susceptibility with schizophrenia. Translation of human genetic mutations into animals is one of the most important strategies to study the pathogenesis of schizophrenia, identify potential drug targets, and test new medicines for antipsychotic treatment. Recent discoveries of susceptibility genes for schizophrenia make the possibility to develop newer genetic mouse models based on the neurodevelopmental hypotheses of schizophrenia. Although it is not possible to mimic all schizophrenic symptoms by these animal models, the genetic mouse models based on the neurodevelopmental hypothesis are widely developed to reproduce several schizophrenia-like behavioral and biochemical changes in humans. In this mini review, we will discuss the neuropathological and behavioral manifestations of representative genetic mouse models for schizophrenia, associated with the hypothesis of abnormal neurodevelopment.
关键词：schizophrenia;genetic mouse model;neurodevelopmental hypothesis