文章基本信息

标题：Lysophosphatidic Acid as the Initiator of Neuropathic Pain
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作者：Hiroshi Ueda
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2011
卷号：34
期号：8
页码：1154-1158
DOI：10.1248/bpb.34.1154
出版社：The Pharmaceutical Society of Japan
摘要：The injury-induced intense stimulation of spinal cord neurons causes lysophosphatidic acid (LPA) biosynthesis. LPA₁ receptor activation causes demyelination and sprouting of dorsal root fibers, leading to an induction of synaptic reorganization underlying allodynia, in which innocuous (tactile) stimuli cause intense pain. The LPA₁ signal also initiates the up-regulation of Ca_vα2δ1 in dorsal root ganglion and PKCγ in the dorsal horn, underlying mechanisms for characteristic neuropathic hyperalgesia in myelinated sensory (A-type) fibers. On the other hand, the LPA₃ receptor mediates microglia activation at the early stage after nerve injury and LPA-induced LPA biosynthesis. Thus, both the LPA₁ and LPA₃ receptors play key roles in the initiation step using a feed-forward system for neuropathic pain.
关键词：lysophosphatidic acid;demyelination;feed-forward system;neuropathic pain;microglia