文章基本信息

标题：Preventive Effect of Chlorogenic Acid on Lens Opacity and Cytotoxicity in Human Lens Epithelial Cells
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作者：Young Sook Kim ; Nan Hee Kim ; Yun Mi Lee 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2011
卷号：34
期号：6
页码：925-928
DOI：10.1248/bpb.34.925
出版社：The Pharmaceutical Society of Japan
摘要：The present study reveals the pharmacological effect of chlorogenic acid, a major phenolic compound in plants, food, and coffee, on diabetic cataracts. Chlorogenic acid examined the inhibitory effects upon rat lens aldose reductase (AR) activity and xylose-induced rat lens opacity. The effect of chlorogenic acid on high glucose-induced cytotoxicity in lens epithelial cells was also examined. Chlorogenic acid showed potential inhibitory activity against rat lens AR, with an IC₅₀ value of 0.95 μ M . The xylose-induced opacity of lenses was significantly improved after treatment with chlorogenic acid in a dose-dependent manner. Chlorogenic acid prevented high glucose-induced cytotoxicity in human lens epithelial (HLE-B3) cells in a dose-dependent manner. These results suggest that chlorogenic acid may provide a potential therapeutic approach for prevention of diabetic complications, such as cataracts.
关键词：chlorogenic acid;aldose reductase;lens opacity;cytotoxicity;human lens epithelial cell