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标题：Therapeutic Effects of Hybrid Liposomes Composed of Phosphatidylcholine and Docosahexaenoic Acid on the Hepatic Metastasis of Colon Carcinoma along with Apoptosis in Vivo
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作者：Hideaki Ichihara ; Keiko Zako ; Yuji Komizu 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2011
卷号：34
期号：6
页码：901-905
DOI：10.1248/bpb.34.901
出版社：The Pharmaceutical Society of Japan
摘要：Therapeutic effects of hybrid liposomes ( L -α-dimyristoylphosphatidylcholine (DMPC)/docosahexaenoic acid (DHA)) composed of 50 mol% DMPC and 50 mol% DHA on the metastasis of human colon carcinoma (HCT116) cells were examined in vivo . DMPC/DHA having a hydrodynamic diameter less than 100 nm were preserved for one month. Remarkably high therapeutic effects were obtained in the hepatic metastasis mouse models of HCT116 cells after the intravenous injection of DMPC/DHA. The histological analysis indicated the induction of apoptosis was observed in the liver section of the hepatic metastasis mouse models treated with DMPC/DHA in vivo . Furthermore, prolonged survival was obtained in the hepatic metastasis mouse models after the treatment with DMPC/DHA. Therapeutic effects of DMPC/DHA without any drugs on the hepatic metastasis were revealed on the basis of histological and biochemical analyses for the first time in vivo .
关键词：hybrid liposome;docosahexaenoic acid;hepatic metastasis;colon carcinoma;apoptosis