文章基本信息

标题：Specific Interaction between Ca2+ and Anionic Lipids in Cancer Cells along with Apoptosis
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作者：Koichi Goto ; Kazuki Tatsumi ; Toshihiro Nagata 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2011
卷号：34
期号：3
页码：439-442
DOI：10.1248/bpb.34.439
出版社：The Pharmaceutical Society of Japan
摘要：Markedly inhibitory effects of Ca²⁺ on the growth of human tumor cells were attained through the induction of apoptosis in vitro . On the other hand, a good correlation between the growth inhibition effects of Ca²⁺ and the amounts of phosphatidylserines (PS) in the cell membranes (plasma membranes) was obtained. Furthermore, the decrease of membrane fluidity and the localization of lipid microdomains “lipid rafts” in the cell membranes were observed in the presence of Ca²⁺. The findings in this study suggest that Ca²⁺ could induce apoptosis toward tumor cells through the localization of lipid rafts in plasma membranes by the specific interactions between extracellular Ca²⁺ and PS.
关键词：calcium;tumor cell;apoptosis;phosphatidylserine;lipid raft