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标题：Ovalicin Ameliorates Compound 48/80-Induced Atopic Dermatitis-Related Symptoms
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作者：Cheol-Sik Yoon ; Sung-Hee Nam ; Ji-Young Jeon 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2011
卷号：34
期号：12
页码：1881-1884
DOI：10.1248/bpb.34.1881
出版社：The Pharmaceutical Society of Japan
摘要：Ovalicin, a secondary metabolite produced by an entomopathogenic fungus Metarhizium anisopliae var. anisopliae , is currently used as an efficient biological control agent against various agricultural insect pests, but not so many biological activities have been investigated. To assess whether ovalicin has potential in ameliorating atopic dermatitis-related symptoms in mice, we first sensitized skin in the dorsal neck of Balb/c mice using compound 48/80, and scrutinized whether the compound affected the atopic dermatitis-related symptoms. The results revealed that ovalicin significantly reduces scratching behavior in a concentration-dependent fashion. Moreover, the treatment inhibits the levels of the degranulation of mast cells by 65%, and levels of histamine release by 51% at a concentration of 10 μg/ml. Together, the present data strongly suggest that ovalicin elicits potential anti-atopic activities in mice.
关键词：ovalicin;atopic dermatitis;scratching;degranulation;histamine