文章基本信息

标题：Evidence for Neuroprotective Effect of Sulbutiamine against Oxygen–Glucose Deprivation in Rat Hippocampal CA1 Pyramidal Neurons
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作者：Jeehyun Kwag ; Aman Shah Abdul Majid ; Kui Dong Kang 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2011
卷号：34
期号：11
页码：1759-1764
DOI：10.1248/bpb.34.1759
出版社：The Pharmaceutical Society of Japan
摘要：Hippocampus is one of the earliest brain regions that gets affected by ischemia, however, no pharmacological therapy exists yet that can fully counteract the ischemic damage. Here we study the effect of sulbutiamine, a synthetic thiamine analogue that can cross the blood–brain barrier easily, on hippocampal neurons under an in vitro model of ischemia, oxygen–glucose deprivation (OGD). We find that exposure to OGD in the presence of sulbutiamine significantly increases neuronal viability and enhances electrophysiological properties such as excitatory synaptic transmissions and intrinsic neuronal membrane input resistance in a concentration-dependent manner. Overall, here we report, for the first time, the neuroprotective evidence of sulbutiamine on hippocampal CA1 pyramidal neurons under OGD, which may have beneficial implications as a possible therapeutic agent/substance against ischemic insult.
关键词：sulbutiamine;oxygen–glucose deprivation;hippocampus;neuroprotection