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标题：Cardiovascular Protection with Danshensu in Spontaneously Hypertensive Rats
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作者：Yiqun Tang ; Minhui Wang ; Chunlin Chen 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2011
卷号：34
期号：10
页码：1596-1601
DOI：10.1248/bpb.34.1596
出版社：The Pharmaceutical Society of Japan
摘要：The objective of the present study was to evaluate the cardiovascular protective effects of Danshensu, a water-soluble active component of Danshen, in spontaneously hypertensive rats (SHR). SHR (male, 9 weeks old, n =30) were divided into three groups: 1) saline control ( n =10); 2) a Danshensu (10 mg/kg/d, intraperitoneally (i.p.)) treatment group ( n =10); and 3) a Valsartan (10 mg/kg/d, intragastrically (i.g.)) treatment group ( n =10). Age-matched Wistar-Kyoto rats ( n =10) were used as normotensive controls. Saline and drug treatments were administered for 6 weeks. When the rats were 15 weeks old, their hearts were excised and arrhythmias were induced by an ex vivo ischemia/reperfusion protocol. The heart weight to body weight index was significantly increased in SHR, and this increase was attenuated with Danshensu treatment (both p <0.05). Systolic blood pressure and diastolic blood pressure were also decreased with Danshensu treatment, from 145±3 and 103±10 mmHg to 116±7 and 87±2 mmHg in SHR and Danshensu-treated groups, respectively (both p <0.05). The incidences of ventricular tachycardia and ventricular fibrillation decreased from 100 to 50% and 30% in SHR, respectively, with Danshensu treatment (both p <0.05). Serum nitric oxide content and inducible nitric oxide synthase activity were significantly increased with Danshensu (both p <0.05). In addition, Danshensu increased the K⁺ current density and Ca²⁺ activated K⁺ channel current density of mesenteric vascular smooth muscle cells isolated from SHRs. Together, these results demonstrate that Danshensu imparts cardiovascular protection by modifying vascular responses during the progression of hypertension.
关键词：Danshensu;hypertrophy;spontaneously hypertensive rat;arrhythmic;Ca+-activated K+ channels