文章基本信息

标题：Human Intestinal Bacterium, Strain END-2 Is Responsible for Demethylation as Well as Lactonization during Plant Lignan Metabolism
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作者：Jong-Sik Jin ; Masao Hattori
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2010
卷号：33
期号：8
页码：1443-1447
DOI：10.1248/bpb.33.1443
出版社：The Pharmaceutical Society of Japan
摘要：A human intestinal bacterium, strain END-2, which enantioselectively oxidizes (+)-enterodiol (END) to (+)-enterolactone (ENL) through enterolactol is also responsible for demethylation during plant lignan metabolism. A free hydroxyl group adjacent to the methoxy group is required for demethylation. The bacterium transformed (+)- and (−)-secoisolariciresinol to (+)-ENL and (−)-END, respectively, by co-incubation with strain ARC-1, which is responsible for dehydroxylation.
关键词：enterolactone;phytoestrogen;human intestinal bacteria