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标题：Melanogenesis Inhibitory Effect of Fatty Acid Alkyl Esters Isolated from Oxalis triangularis
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作者：Sungran Huh ; Young-Soo Kim ; Eunsun Jung 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2010
卷号：33
期号：7
页码：1242-1245
DOI：10.1248/bpb.33.1242
出版社：The Pharmaceutical Society of Japan
摘要：Ten fatty acid alkyl esters isolated from Oxalis triangularis , were evaluated for the effects on melanogenesis using mouse B16 melanoma cells. Treatment of methyl linoleate, methyl linolenate, ethyl linoleate and ethyl linolenate significantly blocked forskolin-induced melanogenesis and inhibited tyrosinase activity. In addition, we found that they inhibited cAMP production, suggesting that their anti-melanogenic effect is mediated by the inhibition of cAMP production. We concluded that methyl/ethyl linoleate and linolenate isolated from Oxalis triangularis have pigment inhibition activity. These compounds may be useful as the cosmetic agent to stimulate skin whitening.
关键词：Oxalis triangularis;melanogenesis;fatty acid alkyl ester