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标题：Hepatoprotective Effect of Syringic Acid and Vanillic Acid on CCl4-Induced Liver Injury
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作者：Ayano Itoh ; Katsuhiro Isoda ; Masuo Kondoh 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2010
卷号：33
期号：6
页码：983-987
DOI：10.1248/bpb.33.983
出版社：The Pharmaceutical Society of Japan
摘要：The mycelia of the edible mushroom Lentinula edodes can be cultured in solid medium containing lignin, and the hot-water extracts (L.E.M.) is commercially available as a nutritional supplement. During the cultivation, phenolic compounds, such as syringic acid and vanillic acid, were produced by lignin-degrading peroxidase secreted from L. edodes mycelia. Since these compounds have radical scavenging activity, we examined their protective effect on oxidative stress in mice with CCl₄-induced liver injury. We examined the hepatoprotective effect of syringic acid and vanillic acid on CCl₄-induced chronic liver injury in mice. The injection of CCl₄ into the peritoneal cavity caused an increase in the serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. The intravenous administration of syringic acid and vanillic acid significantly decreased the levels of the transaminases. Four weeks of CCl₄ treatment caused a sufficiently excessive deposition of collagen fibrils. An examination of Azan-stained liver sections revealed that syringic acid and vanillic acid obviously suppressed collagen accumulation and significantly decreased the hepatic hydroxyproline content, which is the quantitative marker of fibrosis. Both of these compounds inhibited the activation of cultured hepatic stellate cells, which play a central role in liver fibrogenesis, and maintained hepatocyte viability. These data suggest that the administration of syringic acid and vanillic acid could suppress hepatic fibrosis in chronic liver injury.
关键词：hepatoprotection;Lentinula edodes;syringic acid;vanillic acid;polyphenol