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标题：Neuroprotective Effect of Piperine on Primarily Cultured Hippocampal Neurons
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作者：Min Fu ; Zhao-hui Sun ; Huan-cong Zuo 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2010
卷号：33
期号：4
页码：598-603
DOI：10.1248/bpb.33.598
出版社：The Pharmaceutical Society of Japan
摘要：It was previously reported that piperine (PIP) significantly blocks convulsions induced by intracerebroventricular injection of threshold doses of kainate, but had no or only slight effects on convulsions induced by L -glutamate, N -methyl- D -aspartate and guanidinosuccinate. In traditional Chinese medicine, black pepper has been used for epileptic treatment; however, the exact mechanism is still unclear. We reported here in that appropriate concentration of PIP effectively inhibites the synchronized oscillation of intracellular calcium in rat hippocampal neuronal networks and represses spontaneous synaptic activities in terms of spontaneous synaptic currents (SSC) and spontaneous excitatory postsynaptic currents (sEPSC). Moreover, pretreatment with PIP expects protective effect on glutamate-induced decrease of cell viability and apoptosis of hippocampal neurons. These data suggest that the neuroprotective effects of PIP might be associated with suppression of synchronization of neuronal networks, presynaptic glutamic acid release, and Ca²⁺ overloading.
关键词：piperine;calcium oscillation;spontaneous synaptic current;spontaneous excitatory postsynaptic current;glutamate-induced excitotoxicity;hippocampal neuron