文章基本信息

标题：Cellular Lipid Droplets and Hepatitis C Virus Life Cycle
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作者：Masayoshi Fukasawa
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2010
卷号：33
期号：3
页码：355-359
DOI：10.1248/bpb.33.355
出版社：The Pharmaceutical Society of Japan
摘要：Lipid droplets (LDs) are cellular lipid storage organelles involved not only in lipid homeostasis but also in a variety of diseases. Chronic hepatitis C virus (HCV) infection affects host lipid metabolism, and thus induces LD accumulation in the liver. Recent studies have suggested that cellular LDs also play a crucial role in the HCV life cycle. Interactions between HCV proteins, especially the core protein, and LDs are required for the morphogenesis of infectious HCV. The present minireview will summarize the recent research progress about this unique relationship between LDs and the HCV life cycle.
关键词：lipid droplet;hepatitis C virus;core protein