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标题：In Vitro Antibacterial Activity of Phx-3 against Helicobacter pylori
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作者：Tomoko Hanawa ; Takako Osaki ; Taki Manzoku 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2010
卷号：33
期号：2
页码：188-191
DOI：10.1248/bpb.33.188
出版社：The Pharmaceutical Society of Japan
摘要：Phx-3, one of the phenoxazine derivatives, is reported to have inhibitory effect on Mycobacterium species and Chlamydia pneumoniae but not Escherichia coli , Salmonella Typhimurium, Pseudomonas aeruginosa , Staphylococcus aureus , Listeria monocytogenes . The bactericidal activities of Phx-3 against Helicobacter pylori strains have not been assessed. Then, we measured minimum inhibitory concentration of Phx-3 for Helicobacter strains and assessed the morphological and biochemical effects of Phx-3 on H. pylori . In present study, it has shown that H. pylori strains including clarithromycin resistant strain and Helicobacter musterae were killed effectively by the treatment with Phx-3. Furthermore, severe morphological changes such as membrane blebbing and formation of hollows in H. pylori were detected. In addition, induction of heat shock protein 60 was observed. Taken together, Phx-3 has antibacterial activity against Helicobacter pylori .
关键词：Helicobacter pylori;phenoxazine;bactericidal agent