文章基本信息

标题：A Vesicular Transporter That Mediates Aspartate and Glutamate Neurotransmission
本地全文：下载
作者：Takaaki Miyaji ; Hiroshi Omote ; Yoshinori Moriyama 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2010
卷号：33
期号：11
页码：1783-1785
DOI：10.1248/bpb.33.1783
出版社：The Pharmaceutical Society of Japan
摘要：Aspartate, an excitatory amino acid, is known to be stored in synaptic vesicles and exocytosed from some neurons to perform aspartergic neurotransmission. Through in vitro reconstitution, we found that sialin, a lysosomal sialic acid exporter, is responsible for the vesicular storage of aspartate in hippocampal neurons and pinealocytes. Mutations found in Salla disease cause decreased aspartate transport activity without affecting sialic acid transport. Thus, sialin is a multifunctional transporter. It is possible that people with Salla disease lose the ability of aspartergic neurotransmission, and this could explain why Salla disease involves severe neurological defects.
关键词：aspartate;neurotransmission;Salla disease;vesicular excitatory amino acid transporter;veicular glutamate transporter