文章基本信息

标题：Association of the A-1438G Polymorphism in Serotonin 2A Receptor in Migraine with Aura among Japanese Patients
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作者：Yuika Naito ; Masakazu Ishii ; Ayumu Nagamine 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2010
卷号：33
期号：10
页码：1751-1753
DOI：10.1248/bpb.33.1751
出版社：The Pharmaceutical Society of Japan
摘要：We investigated the possible association of serotonin (5-HT) 2A receptor gene A-1438G polymorphism in Japanese patients with migraine. Genotyping of 5-HT_2A A-1438G polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism in patients with migraine (male 17 : 3 with aura and 14 without aura, female 65 : 17 with aura and 48 without aura) and controls (male 31, female 84). The distribution of 5-HT_2A A-1438G genotype frequency between migraine patients and controls did not differ. These results suggest that the A-1438G polymorphism of the 5-HT_2A receptor gene is not a direct risk factor for migraine; however, the incidence of the A / A genotype between migraine with aura (MA) and without aura (MO) was significantly different. The 5-HT_2A A-1438G polymorphism may be involved in determining the subtypes of migraine in Japanese.
关键词：migraine;aura;A-1438G polymorphism;serotonin 2A receptor