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标题：Preventive Effect of Green Tea Catechins on Experimental Tumor Metastasis in Senescence-Accelerated Mice
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作者：Kosuke Shimizu ; Naomi Kinouchi Shimizu ; Wakako Hakamata 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2010
卷号：33
期号：1
页码：117-121
DOI：10.1248/bpb.33.117
出版社：The Pharmaceutical Society of Japan
摘要：Successful avoidance of the immune surveillance system is critical for the development of a blood–borne metastasis. Previous findings suggest that experimental tumor metastasis was enhanced in senescence-accelerated mice prone 10 (SAMP10) due to a reduction in immune surveillance potential with age. In the present study, water containing green tea (GT)-catechins was freely given to SAMP10 mice, and the chemopreventive effect of GT-catechin intake on tumor metastasis was examined. Natural killer cell activity, which is an indicator of immune surveillance potential and is reduced in control mice with age, was maintained by GT-catechin intake. The early accumulation of lung-metastatic K1735M2 melanoma cells in lungs after intravenous injection of the cells and subsequent experimental lung metastasis was investigated in mice given GT-catechins. The accumulation at 6 and 24 h after injection of K1735M2 cells was significantly suppressed, and the number of lung-metastatic colonies was significantly reduced, in comparison with those in control mice. The results suggest that GT-catechin intake prevented the experimental tumor metastasis in aged SAMP10 mice via its inhibition of a reduction in immune surveillance potential with age.
关键词：aging;tumor metastasis;green tea catechin;immune surveillance