文章基本信息

标题：Participation of Prostaglandin E2 Receptor in Nasal Congestion of Brown Norway Rats
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作者：Yasunori Kurata ; Atsuki Yamamoto ; Kana Izawa 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2010
卷号：33
期号：1
页码：64-66
DOI：10.1248/bpb.33.64
出版社：The Pharmaceutical Society of Japan
摘要：The aim of the present study was to clarify the involvement of prostaglandin E₂ (PGE₂) in nasal congestion in Brown Norway (BN) rats. For this purpose, we studied the effects of PGE₂ receptor (EP₁, EP₂, EP₃ and EP₄) agonists on nasal congestion and sneezing induced by toluene 2,4-diisocyanate (TDI). Enhanced pause (Penh) was increased 1 h (early phase) and 4 h (late phase) after TDI challenge. Sulprostone (an EP₃ receptor agonist) inhibited the increase of Penh, an index of nasal congestion, in both early and late phase responses. On the other hand, PGE₁ alcohol (an EP₄ agonist) increased Penh in the early phase response. Moreover, sulprostone inhibited sneezing, an immediate response by TDI challenge. These results indicate that EP₃ receptor is responsible for the relief of nasal congestion in both early and late phase responses, and EP₄ receptor is correlated with the development of nasal congestion in the early phase response. In addition, EP₃ receptor also participates in sneezing in allergic rhinitis induced by TDI challenge in BN rats.
关键词：nasal congestion;enhanced pause;prostaglandin E2;toluene 2,4-diisocyanate;Brown Norway rat