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标题：Deoxypodophyllotoxin Inhibits the Expression of Intercellular Adhesion Molecule-1 Induced by Tumor Necrosis Factor-α in Murine Lung Epithelial Cells
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作者：Meihua Jin ; Eunkyung Lee ; Ju Hye Yang 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2010
卷号：33
期号：1
页码：1-5
DOI：10.1248/bpb.33.1
出版社：The Pharmaceutical Society of Japan
摘要：Intercellular adhesion molecule-1 (ICAM-1) is associated with processes of inflammation. We investigated the effects of deoxypodophyllotoxin (DPT) on tumor necrosis factor-α (TNF-α) induced ICAM-1 expression in the mouse lung epithelial cell line, LA4. DPT (5 to 20 n M ) inhibited TNF-α-induced ICAM-1 expression through nuclear factor-kappa B (NF-κB) in a dose-dependent manner and repressed ICAM-1 promoter activity. NF-κB reporter gene activity and DNA binding activity were also strongly inhibited. In addition, DPT inhibited degradation by the TNF-α induced inhibitory κB-α (IκB-α) in a concentration-dependent manner. Taken together with our previous results suggest DPT might provide a basis for novel anti-inflammatory drug development.
关键词：deoxypodophyllotoxin;tumor necrosis factor-α;intercellular adhesion molecule-1;nuclear factor-kappa B;lipopolysaccharide