文章基本信息

标题：Inhibitory Effects of Flavonoid Glycosides Isolated from the Peel of Japanese Persimmon (Diospyros kaki ‘Fuyu’) on Melanin Biosynthesis
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作者：Kenji Ohguchi ; Chizuru Nakajima ; Masayoshi Oyama 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2010
卷号：33
期号：1
页码：122-124
DOI：10.1248/bpb.33.122
出版社：The Pharmaceutical Society of Japan
摘要：We found that the acetone extract of the peel of Japanese persimmon ( Diospyros kaki ‘Fuyu’) inhibits melanin biosynthesis in mouse B16 melanoma cells. The activity-guided purification of the extract resulted in isolation of two active compounds, which have been identified as flavonoid glycosides, isoquercitrin (quercetin-3- O -glucoside) and hyperin (quercetin-3- O -galactoside) by spectral analysis. Isoquercitrin and hyperin strongly inhibited the production of melanin (IC₅₀: 21.7 and 18.2 μ M , respectively). The inhibitory effects were found to be mediated by suppression of tyrosinase expression.
关键词：melanin;tyrosinase;persimmon;kaki;flavonoid