文章基本信息

标题：Depigmentation of Melanocytes by (2Z,8Z)-Matricaria Acid Methyl Ester Isolated from Erigeron breviscapus
本地全文：下载
作者：Lian Hua Luo ; Hae Jong Kim ; Dung Hoang Nguyen 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2009
卷号：32
期号：6
页码：1091-1094
DOI：10.1248/bpb.32.1091
出版社：The Pharmaceutical Society of Japan
摘要：To discover an active skin depigmenting agent, we isolated a novel inhibitor of melanin biosynthesis from the methanol extract of Erigeron breviscapus using a bioactivity-guided fractionation and identified it as (2 Z ,8 Z )-matricaria acid methyl ester by means of spectroscopic analysis. The compound showed strong whitening activity in melan-a cell. Compared with arbutin (IC₅₀=4.0 m M ) as a positive control, the depigmentation IC₅₀ value for (2 Z ,8 Z )-matricaria acid methyl ester was 25.4 μ M in B16F10 melanoma cell. Moreover, its inhibitory effect on tyrosinase, the key enzyme of melanogenesis, was examined by in vivo and in vitro tyrosinase assay and Western blot. The results indicate that (2 Z ,8 Z )-matricaria acid methyl ester isolated from Erigeron breviscapus is a promising compound that could be useful for treating hyper-pigmentation as skin-whitening agents.
关键词：melanin;Erigeron breviscapus;(2Z,8Z)-matricaria acid methyl ester;skin whitening