文章基本信息

标题：Cytoprotective Constituents of the Heartwood of Caesalpinia sappan on Glutamate-Induced Oxidative Damage in HT22 Cells
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作者：Gil-Saeng Jeong ; Dong-Sung Lee ; Tae-Oh Kwon 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2009
卷号：32
期号：5
页码：945-949
DOI：10.1248/bpb.32.945
出版社：The Pharmaceutical Society of Japan
摘要：The bioassay-guided fractionation of a MeOH extract of the heartwood of Caesalpinia sappan L. provided two neuroprotective compounds, sappanchalcone (2) and 4- O -methylepisappanol (3), together with a methoxychalcone, isoliquiritigenin 2′-methyl ether (1), and three aromatic compounds, 4- O -methylsappanol (4), caesalpine J (5), pluchoic acid (6). At concentrations of 20—40 μm, compound 2 showed significant cytoprotective effects against glutamate-induced oxidative stress through the induction of heme oxygenase (HO)-1 in HT22-immortalized hippocampal cells. Compound 3 also showed moderate neuroprotective effect at 40 μm, but compounds 1, 4—6 did not show any protective effects against glutamate-induced cytotoxicity in HT22 cells.
关键词：Caesalpinia sappan;neuroprotective;glutamate;HT22 cell;heme oxygenase-1