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标题：Anti-inflammatory Constituents of Sappan Lignum
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作者：Makiko Washiyama ; Yohei Sasaki ; Tomokazu Hosokawa 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2009
卷号：32
期号：5
页码：941-944
DOI：10.1248/bpb.32.941
出版社：The Pharmaceutical Society of Japan
摘要：We performed an in vitro assay for seven compounds from methanolic extract of Sappan Lignum (CSE) that inhibit the chemical mediators of inflammation using the J774.1 cell line: brazilin (1), sappanchalcone (2), protosappanin A (3), protosappanin B (4), protosappanin C (5), protosappanin D (6), and protosappanin E (7). Those compounds were evaluated for their inhibitory effects on nitric oxide (NO) and prostaglandin E₂ (PGE₂) production and their suppressive effects on tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) mRNA expression. As a result, we clarified that 1 inhibited NO production, and almost no inhibition in PGE₂. On the contrary, 2, 6, and 7 inhibited both NO and PGE₂ production and suppressed TNF-α, IL-6, COX-2, and iNOS mRNA expression. An examination of carrageenin-induced mouse paw edema suggested that the CSE contained active compounds other than 1, the main constituent in CSE. It was thus revealed that several compounds and mechanisms contributed to the anti-inflammatory effect of CSE.
关键词：Caesalpinia sappan L.;Sappan Lignum;anti-inflammatory effect;brazilin;carrageenin