首页    期刊浏览 2024年11月30日 星期六
登录注册

文章基本信息

  • 标题:Pharmaceutically Important Pre- and Posttranslational Modifications on Human Serum Albumin
  • 本地全文:下载
  • 作者:Masaki Otagiri ; Victor Tuan Giam Chuang
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2009
  • 卷号:32
  • 期号:4
  • 页码:527-534
  • DOI:10.1248/bpb.32.527
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Recombinant technology allows engineering and production of proteins with desirable properties. Human serum albumin has been developed with recombinant technology, and thus plays an increasing role as a drug carrier in the clinical setting. Genetic variations usually occur on the surface of the protein, and do not impose significant effects on the conformation of albumin. However, binding of fatty acids by genetic variants is affected according to the location of the mutation. Albumin undergoes three major posttranslational modifications, namely, oxidation, glycation, and S -nitrosylation. This review gives an account of the different posttranslational modifications that should be taken into consideration when designing albumin mutant analogues with desirable pharmaceutical properties.
  • 关键词:human serum albumin;genetic variant;posttranslational modification: oxidation;glycation;S-nitrosylation
国家哲学社会科学文献中心版权所有