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标题：Pharmacological Analysis of Antigen-Induced Late Airway Response in Rats
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作者：Naoki Miyagawa ; Hidenori Iwasaki ; Toshinobu Kato 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2009
卷号：32
期号：3
页码：394-398
DOI：10.1248/bpb.32.394
出版社：The Pharmaceutical Society of Japan
摘要：The pharmacological and pathophysiological characteristics of rat antigen-induced late airway response (LAR) are not yet fully understood. In this study, the pharmacological properties of rat ovalbumin (OVA)-induced LAR and effects of the clinically used anti-asthmatic drugs salbutamol (β₂-agonist), ketotifen (antihistamine), pranlukast (anti-leukotriene C₄/D₄/E₄), and prednisolone (steroid) were examined. In addition, a comparison was made of cell infiltration in bronchoalveolar lavage fluid (BALF) between immediate airway response (IAR) and LAR, and the edematous features of lung during LAR were also examined. Although infiltration of inflammatory cells into BALF was increased in both IAR and LAR, only the increase in eosinophils at 1, 3, and 6 h during LAR were significantly higher than those during IAR. Although β₂-agonist, antihistamine, and anti-leukotriene C₄/D₄/E₄ exhibited no effects on rat LAR, steroid attenuated LAR and decreased eosinophil number in BALF. LAR and the percentage water content were both increased after antigen inhalation, suggesting that LAR is involved in pulmonary edema in rats. In conclusion, antigen-induced LAR was related to pulmonary edema and eosinophil infiltration rather than contraction of airway smooth muscle. This is the first comprehensive study of the profiles of rat antigen-induced LAR, and these analyses of LAR improve understanding of the diverse mechanisms underlying human asthmatic diseases.
关键词：late airway response;antiasthmatic drug;eosinophil infiltration;edema