文章基本信息

标题：μ-Opioid and N-Methyl-D-aspartate Receptors Are Localized at Laryngeal Motoneurons of Guinea Pigs
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作者：Hiromi Yamazaki ; Yoshiaki Ohi ; Akira Haji 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2009
卷号：32
期号：2
页码：293-296
DOI：10.1248/bpb.32.293
出版社：The Pharmaceutical Society of Japan
摘要：The glottic movement is important for generating efficient airflow in respiration and related reflexes such as coughing. The superior laryngeal nerve (SLN) innervates the cricothyroid muscle and regulates the glottic aperture. A total of 620 laryngeal motoneurons (LMNs) providing efferent fibers to the SLN were retrogradely identified with fluorescent wheat germ agglutinin (WGA) in 8 guinea pigs. The WGA-labeled cells were distributed in the ventrolateral part of nucleus ambiguus, extending 1.8—2.2 mm lateral to the midline, 0.8—1.2 mm from the ventral surface and 1.7—2.6 mm rostral to the obex. Double staining revealed that 28.4% of LMNs (44 out of 155 cells examined) were immunopositive to N -methyl- D -aspartate (NMDA) receptors and 29.2% of LMNs (55 out of 185 cells) to μ-opioid receptors. The present study demonstrates phenotypic variation in the synaptic transmission to the LMNs in guinea pigs. These results suggest modulation of the glottic movement by μ-opioid and NMDA mechanisms.
关键词：laryngeal motoneuron;μ-opioid receptor;N-methyl- D -aspartate receptor;guinea pig