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标题：Goshuyuto, a Traditional Japanese Medicine, and Aqueous Extracts of Evodiae Fructus Constrict Isolated Rat Aorta via Adrenergic and/or Serotonergic Receptors
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作者：Tomoko Hibino ; Mitsutoshi Yuzurihara ; Hitomi Kanno 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2009
卷号：32
期号：2
页码：237-241
DOI：10.1248/bpb.32.237
出版社：The Pharmaceutical Society of Japan
摘要：Effects of goshuyuto, a traditional Japanese medicine, on vascular constriction were examined using isolated strips of rat aorta. Goshuyuto (1×10⁻⁵ to 1×10⁻³ g/ml) caused constriction of aorta strips in a dose-dependent manner. The vasoconstrictive effects of goshuyuto were significantly inhibited by pretreatment with prazosin, an adrenergic α₁ receptor antagonist. The constrictive effects were partially inhibited by pretreatment with BRL15572, a 5-HT_1D antagonist, and ketanserin, a 5-HT_2A antagonist. However, the constrictive effects were not inhibited by pretreatment with SB216641, a 5-HT_1B antagonist, or propranolol, an adrenergic β receptor antagonist. In addition, aqueous extracts of Evodiae Fructus , one of the constituent medicinal herbs of goshuyuto, caused constriction of aorta strips strongly, but aqueous extracts of Zizyphi Fructus , Ginseng Radix , and Zingiberis Rhizoma , the other constituents of goshuyuto, did not have much effect on the vascular response of rat aorta strips. Also, synephrine, which is one of the ingredients of Evodiae Fructus , constricted the rat aorta. These results suggest that goshuyuto constricts rat aorta strips and that the mechanisms involve the adrenergic and/or serotonergic receptors. Also, it may be suggested that Evodiae Fructus and synephrine play the important role in the vasoconstrictive effects of goshuyuto on rat aorta strips.
关键词：goshuyuto;adrenergic α1;5-HT1D;5-HT2A;Evodiae Fructus;synephrine