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标题：Inhibition of Human Gastric Carcinoma Cell Growth in Vitro and in Vivo by Cladosporol Isolated from the Paclitaxel-Producing Strain Alternaria alternata var. monosporus
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作者：Jiepeng Chen ; Xuelian Qiu ; Ronghua Wang 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2009
卷号：32
期号：12
页码：2072-2074
DOI：10.1248/bpb.32.2072
出版社：The Pharmaceutical Society of Japan
摘要：Cladosporol was isolated from the fermentation broth of Alternaria alternata var. monosporus obtained from the inner bark of the yew tree and mutated for many generations. We investigated the antitumor effects of cladosporol in vitro and in vivo . The growth-inhibitory effects of cladosporol in vitro against six human cancer cell lines were examined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The results showed that cladosporol selectively killed cancer cells and had a significant inhibitory effect on the human gastric carcinoma cell line MGC-803 in a concentration- and time-dependent manner. In vivo , cladosporol also showed antitumor activity in nude mice bearing MGC-803 gastric cancer xenografts. These findings suggest that cladosporol has potentially useful growth inhibitory effects on human gastric carcinoma cell lines.
关键词：cladosporol;cytotoxicity;human gastric carcinoma cell line MGC-803;Alternaria alternata