文章基本信息

标题：Effects of Inhibiting the Proteasomal Degradation of Estrogen Receptor α on Estrogen Receptor α Activation under Hypoxic Conditions
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作者：Yeo Myeong Park ; Jung Yoon Cho ; Young Do Koo 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2009
卷号：32
期号：12
页码：2057-2060
DOI：10.1248/bpb.32.2057
出版社：The Pharmaceutical Society of Japan
摘要：Hypoxia, which is intimately associated with the biology of breast carcinomas, modulates the level of estrogen receptor (ER) α expression and transactivation. We investigated the effect of blocking ER degradation on ERα-mediated transactivation under hypoxic conditions using the proteasome inhibitor MG132. Pretreatment with MG132 blocked hypoxia-induced degradation of ERα protein. Our data imply that ERα proteasomal inhibition is linked to receptor transactivation under hypoxia.
关键词：estrogen;estrogen receptor;hypoxia;proteasome inhibition