文章基本信息

标题：Examination of the Expression of Cyclooxygenase-2 in Placenta Villi from Sufferers of Pregnancy Induced Hypertension
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作者：Masaki Okawara ; Hiroyuki Seki ; Kikumi Matsuoka 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2009
卷号：32
期号：12
页码：2053-2056
DOI：10.1248/bpb.32.2053
出版社：The Pharmaceutical Society of Japan
摘要：Objectives : The purpose of this paper is to elucidate the roles of phospholipase A₂ (PLA₂), cyclooxygenase-2 (COX-2), and prostaglandin I₂ (PGI₂) synthase in pregnancy induced hypertension (PIH). Methods : In placentas from normal pregnant women and pregnant women with severe PIH, the enzyme expression of PLA₂, COX-2, and PGI₂ synthase was measured using real time reverse transcription-polymerase chain reaction (RT-PCR). Results : The expression of each enzyme was compared between normal ( n =12) and PIH ( n =12) groups. The expression levels of COX-2 and PGI₂ synthase during PIH pregnancy were significantly decreased to about 51% and 68%, respectively, of their values in normal pregnancy. However, the expression of PLA₂ was hardly changed by PIH. Conclusions : The decreases in COX-2 and PGI₂ synthase expression in severe PIH placentas may be causal factors in the disruption of the PGI₂–thromboxane A₂ (TXA₂) balance in favor of TXA₂. The decrease in COX-2 was more marked than that of PGI₂ synthase.
关键词：pregnancy induced hypertension;cyclooxygenase;placenta;prostaglandin I2;phospholipase A2